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Re: [BKARTS] ortho-phenylphenol anyone?



The carcinogenicity of the biocide ortho-phenylphenol
APPEL K. E.
Division for Plant Protection Products and Pesticides, Federal Institute for 
Health Protection of Consumers and Veterinary Medicine, 14191 Berlin, ALLEMAGNE
Archives of Toxicology  
2000, vol. 74, no2, pp. 61-71 (1 p.3/4)
 
The biocides ortho-phenylphenol and its sodium salt (OPP and SOPP) are widely 
used as fungicides and antibacterial agents for commercial and consumer 
purposes. The carcinogenicity of OPP/SOPP toward the urinary bladder was 
demonstrated when rats were chronically fed concentrations of 0.5%-4% in their diet. 
Other species tested so far did not develop tumours. Understanding the mechanisms 
underlying OPP/SOPP-induced bladder carcinogenesis is critical to determine 
whether risks observed at high doses in rats are of relevance to humans exposed 
at much lower levels. This overview details experimental studies of 
carcinogenicity, genotoxicity as well as metabolism/toxicokinetics and other 
mechanistic studies which bear on cancer hazard and risk evaluation of exposure to 
humans. Based on the presently available knowledge, it is concluded that reactive 
quinoid metabolites exhibiting redox cycling activities are the crucial 
factors. At certain concentration levels, these metabolites are able to produce 
cytotoxic events with concomitant enhanced cell proliferation of the target tissue. 
Further important risk factors are probably promutagenic lesions induced by 
oxidative stress and a higher urinary pH. Supposed that these mechanisms are 
the basis for the tumourigenicity observed, then suitable low doses of OPP/SOPP 
will practically pose no cancer risk.



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